Richard L. Theriault |
Breast cancer occurring during pregnancy is an extremely challenging clinical event. There are very limited data in the literature indicating how to manage patients with this condition. My colleagues and I have developed a prospective clinical practice protocol for the treatment of primary breast cancer occurring during pregnancy. In addition to collecting data on treatment outcomes, we are interested in the effects of treatment on the fetus and neonate, complications of delivery, and long-term effects on childhood growth and development. In the area of bone metastases, we have continued clinical trial development of a new bisphosphonate for patients with osteolytic metastases from breast cancer. New data regarding the relationship between osteoclasts and osteoblasts has led to a trial of pamidronate disodium, an agent aimed at interfering with the cancer cell/osteoclast-mediated destruction of bone. The Women's Healthy Eating and Living Study has examined the effects of a plant-based diet on the risk of recurrence of primary breast cancer. More than 400 women have been enrolled at M. D. Anderson, contributing to the success of this multi-institutional study. In 1997, the National Comprehensive Cancer Network began an ambitious project to determine if guidelines for cancer care can affect an oncology practice. The results are reviewed at the annual Network meeting. I serve as the principal investigator for M. D. Anderson on this ongoing project to assess long-term outcomes of care. |